The strategic planning of this study is based upon using the nanoformulation method to prepare nanoparticles 4-SLNs and 4-LPHNPs of the previously prepared 4. 5-diphenyl-1H-pyrazolo[3. 4-c]pyridazin-3-amine (4) after confirming its structure with single crystal X-ray analysis. These nanoparticles exhibited promising cytotoxic activity against HepG-2. https://www.lightemupsequences.com/flash-sale-Bachelorette-Party-Decorative-Picks-Pack-of-24-mega-choice