There exists a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lower afferent agony transmission and deliver analgesia. For that reason, medicine like clonidine that goal alpha-two receptors can affect the transmission of suffering. Applies to clonidine: oral tablet, https://www.proleviate.com/post/the-new-pain-killer-conolidine